Sheridan made her debut in the US primetime soap opera Paper Dolls in 1984, but her breakthrough came in 1986, when she joined the cast of the CBS primetime soap Knots Landing as "Paige Matheson". She started out in a recurring role, but was a series regular by the 1988-89 season. For her performance in the role, she won the 1990 Soap Opera Digest Award for "Outstanding Lead Actress: Prime Time" and the 1991 Soap Opera Digest Award for "Outstanding Heroine: Prime Time".The same year, she was named one of People Magazine's "50 Most Beautiful People".After the series ended in 1993, she appeared in several made-for-TV movies and the films Spy Hard and Beverly Hills Ninja and auditioned for the role of Grace Adler on Will & Grace (on which she would later guest-star).
On April 5, 2010, Sheridan filed a $20 million lawsuit against Desperate Housewives creator and producer Marc Cherry and ABC, alleging that she was assaulted by Cherry on the set of the show and was wrongfully fired when she reported the alleged abuse to the network. In her lawsuit, Sheridan claimed wrongful termination, assault and battery, gender violence, discrimination based on sex, sexual orientation and age, and intentional infliction of emotional distress. She also claimed that Cherry was abusive to other cast members and writers. ABC responded in a statement saying that while they were unaware of this particular complaint, they had investigated similar claims made by Sheridan and found them to be of no merit.
Nicollette Sheridan accessories
After their break-up, Sheridan returned to ex-boyfriend Michael Bolton, whom she had originally met in 1991.Bolton proposed on holiday in the Bahamas in March 2006.Sheridan was quoted as saying: "It's much sweeter the second time around." In 2006, Sheridan and Bolton sang a duet, "The Second Time Around", for the album Bolton Swings Sinatra.In March 2008, Sheridan posed naked for a London Fog charity ad which also featured Bolton.Sheridan and Bolton broke off the engagement later that year.She dated professional skater Dorien Walker